ABSTRACT
The purpose was to evaluate the influence of a NSAID, Diclofenac Sodium (DFS) on the tissue reaction related to orthodontic tooth movement (OTM). Methods: 27 adult male wistar rats were divided into 3 Groups of 9 each. Orthodontic closed coil spring was placed between rat incisor and molar to produce a 50 gm of force. The experimental Groups1 and 2 received orthodontic force and either DFS of 0.0025mg/0.05ml or 0.05ml of saline, Group 3 received only orthodontic force and served as a control group. At the end of day 5, 10 and 15 the animals were sacrificed and histological examination was performed. Results: Student’s t test showed a statistically significant difference between the control Groups and experimental Groups. Group 1 showed a statistically significant reduction in osteoclastic cell count at day 5, 10 and15 when compared to Group 2 and Group 3. Conclusion: The results indicate that the Diclofenac Sodium even at low concentration level diminishes the number of osteoclasts probably by inhibiting the secretion of prostaglandins there by reducing the OTM.
ABSTRACT
Antibacterial activities of three medicinal plants [Cassia occidentalis, Clerodendrum inerme and Rhinacanthus nasutius] against the skin pathogenic micro-organisms Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pyogenes were evaluated. Effects of aqueous extracts of leaves and roots were assessed by disc diffusion method. All the skin pathogens were re-sensitive to all plant extracts of leaves and roots. Clerodendrum inerme showed broad spectrum antibacterial property as its leaves and root extracts were inhibitory to all the micro-organisms and were more effective than other plant extracts